Published 2021-07-17
Keywords
- Psychological Stress,
- Immunity,
- Cytokines,
- HPA Axis,
- Chronic
How to Cite
Copyright (c) 2021 Jagdish Narayan Saini , Vivek Bhardwaj, Himakshie Bharadwaj
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Background: Stress is the most influential entity of our lives today. Our body’s defence system allows us to withstand stressful conditions. This ability might get altered if the person lives in a stressed environment over an extended time period. The objective of this review article is to understand how psychological stress impacts our immune system. Methodology: The study was conducted during the period May-June 2020. The literature review was made using online libraries like PubMed and Google Scholar. Result: It was thus understood that psychological stress would supress the immune system by shifting from Th1 subset to Th2 subset of cells and through the actions of hypothalamus-pituitary-adrenal axis and sympathetic nervous system. Thus, making the body vulnerable to many diseases and unable to respond adequately to certain infections, injury or vaccinations. Conclusion: Chronic stress can lead to potential adverse effects on the immune system. The interventional methods for stress management might be helpful in improving immune responses of stressed patients.
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References
- Antoni, M. H., Dhabhar, F. S. (2019). The impact of psychosocial stress and stress management on immune responses in patients with cancer. Cancer, 125(9), 1417-1431. https://doi.org/10.1002/cncr.31943
- Arck, P. C., Slominski, A., Theoharides, T. C., Peters, E. M., Paus, R., (2006). Neuroimmunology of stress: skin takes center stage. Journal of Investigative Dermatology, 126(8), 1697-1704. https://doi.org/10.1038/sj.jid.5700104
- Danese, A., Lewis, S. J., (2017). Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?. Neuropsychopharmacology, 42(1), 99-114. https://doi.org/10.1038/npp.2016.198
- Glaser, R., Kiecolt-Glaser, J. K., (2005). Stress-induced immune dysfunction: implications for health. Nature Reviews Immunology, 5(3), 243-251. https://doi.org/10.1038/nri1571
- Godbout, J. P., Glaser, R., (2006). Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. Journal of Neuroimmune Pharmacology, 1(4), 421-427. https://doi.org/10.1007/s11481-006-9036-0
- Gouin, J. P., Hantsoo, L. Kiecolt-Glaser, J. K., (2008). Immune dysregulation and chronic stress among older adults: a review. Neuroimmunomodulation, 15(4-6), 251-259. https://doi.org/10.1159/000156468
- Gouin, J. P., Kiecolt-Glaser, J. K., (2011). The impact of psychological stress on wound healing: methods and mechanisms. Immunology and Allergy Clinics, 31(1), 81-93. https://doi.org/10.1016/j.iac.2010.09.010
- Hall, J. M., Podawiltz, A., Mummert, D. I., Jones, H., Mummert, M. E., (2012). Psychological stress and the cutaneous immune response: roles of the HPA axis and the sympathetic nervous system in atopic dermatitis and psoriasis. Dermatology research and practice, 2012, 1-12. https://doi.org/10.1155/2012/403908
- Menard, C., Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., Takahashi A., Flanigan M.E., Aleyasin H., LeClair K.B., Janssen W.G., Labonté B., Parise E.M., Lorsch Z.S., Golden S.A., Heshmati M., Tamminga C., Turecki G., Campbell M., Fayad Z.A., Tang C.Y., Merad M., Russo S.J., (2017). Social stress induces neurovascular pathology promoting depression. Nature neuroscience, 20(12), 1752-1760. https://doi.org/10.1038/s41593-017-0010-3
- Priyadarshini, S., Aich, P., (2012). Effects of psychological stress on innate immunity and metabolism in humans: a systematic analysis. PloS One, 7(9) e43232. https://dx.doi.org/10.1371%2Fjournal.pone.0043232
- Rosa, M. J., Lee, A., Wright, R. J., (2018). Evidence establishing a link between prenatal and early life stress and asthma development. Current opinion in allergy and clinical immunology, 18(2), 148–158. https://dx.doi.org/10.1097%2FACI.0000000000000421
- Schakel, L., Veldhuijzen, D. S., Crompvoets, P. I., Bosch, J. A., Cohen, S., van Middendorp, H., Joosten S.A., Ottenhoff T.H.M., Visser L.G., Evers A.W.M., (2019). Effectiveness of stress-reducing interventions on the response to challenges to the immune system: a meta-analytic review.Psychotherapy and psychosomatics, 88(5), 274-286. https://dx.doi.org/10.1159%2F000501645
- Vitlic, A., Lord, J. M., Phillips, A. C., (2014). Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system. Age, 36(3), 9631. https://doi.org/10.1007/s11357-014-9631-6