Effects of Psychological Stress on Immune System
- Psychological stress,
- HPA axis,
How to Cite
Copyright (c) 2021
This work is licensed under a Creative Commons Attribution 4.0 International License.
Background: Stress is the most influential entity of our lives today. Our body’s defence system allows us to withstand stressful conditions. This ability might get altered if the person lives in a stressed environment over an extended time period. The objective of this review article is to understand how psychological stress impacts our immune system. Methodology: The study was conducted during the period May-June 2020. The literature review was made using online libraries like PubMed and Google Scholar. Result: It was thus understood that psychological stress would supress the immune system by shifting from Th1 subset to Th2 subset of cells and through the actions of hypothalamus-pituitary-adrenal axis and sympathetic nervous system. Thus, making the body vulnerable to many diseases and unable to respond adequately to certain infections, injury or vaccinations. Conclusion: Chronic stress can lead to potential adverse effects on the immune system. The interventional methods for stress management might be helpful in improving immune responses of stressed patients.
- Antoni, M. H., & Dhabhar, F. S. (2019), The impact of psychosocial stress and stress management on immune responses in patients with cancer, Cancer, 125(9), 1417-1431. https://dx.doi.org/10.1002%2Fcncr.31943
- Arck, P. C., Slominski, A., Theoharides, T. C., Peters, E. M., & Paus, R. (2006), Neuroimmunology of stress: skin takes center stage, Journal of Investigative Dermatology, 126(8), 1697-1704. https://doi.org/10.1038/sj.jid.5700104
- Danese, A., & Lewis, S. J. (2017), Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?, Neuropsychopharmacology, 42(1), 99-114. https://www.nature.com/articles/npp2016198
- Glaser, R., & Kiecolt-Glaser, J. K. (2005), Stress-induced immune dysfunction: implications for health, Nature Reviews Immunology, 5(3), 243-251.
- Godbout, J. P., & Glaser, R. (2006), Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer, Journal of Neuroimmune Pharmacology, 1(4), 421-427.
- Gouin, J. P., &Kiecolt-Glaser, J. K. (2011), The impact of psychological stress on wound healing: methods and mechanisms, Immunology and Allergy Clinics, 31(1), 81-93. https://doi.org/10.1016/j.iac.2010.09.010
- Gouin, J. P., Hantsoo, L., & Kiecolt-Glaser, J. K. (2008), Immune dysregulation and chronic stress among older adults: a review, Neuroimmunomodulation, 15 (4-6), 251-259. https://doi.org/10.1159/000156468
- Hall, J. M., Podawiltz, A., Mummert, D. I., Jones, H., & Mummert, M. E. (2012), Psychological stress and the cutaneous immune response: roles of the HPA axis and the sympathetic nervous system in atopic dermatitis and psoriasis, Dermatology research and practice, 2012. https://doi.org/10.1155/2012/403908
- Menard, C., Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., & Janssen, W. G. (2017), Social stress induces neurovascular pathology promoting depression, Nature neuroscience, 20(12), 1752-1760. https://www.nature.com/articles/s41593-017-0010-3
- Priyadarshini, S., & Aich, P. (2012), Effects of psychological stress on innate immunity and metabolism in humans: a systematic analysis, PloS one, 7(9), e43232. https://dx.doi.org/10.1371%2Fjournal.pone.0043232
- Rosa, M. J., Lee, A., & Wright, R. J. (2018), Evidence establishing a link between prenatal and early life stress and asthma development, Current opinion in allergy and clinical immunology, 18(2), 148-158. https://dx.doi.org/10.1097%2FACI.0000000000000421
- Schakel, L., Veldhuijzen, D. S., Crompvoets, P. I., Bosch, J. A., Cohen, S., van Middendorp, H., & Evers, A. W. (2019), Effectiveness of stress-reducing interventions on the response to challenges to the immune system: a meta-analytic review, Psychotherapy and psychosomatics, 88(5), 274-286. https://dx.doi.org/10.1159%2F000501645
- Vitlic, A., Lord, J. M., & Phillips, A. C. (2014), Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system, Age, 36(3), 9631.